Molds are identified by LAB 797 using various protein analysis and staining techniques. It is highly recommended that your pharmacy take action according to your SOP (Standard Operating Procedure) upon receiving such results.
Below are some common molds that may be on your reports.
Cladosporium sp.
Commonly isolated indoors or outdoors, usually on plant material
Species have dark green-black colonies
Grows well on surfaces where moisture is present
Rarely pathogenic in humans, but may cause allergies and nail infections
Penicillium sp.
Isolated in the environment and common in food spoilage and drug production
Species have blue-green-yellow-brown colonies
Grows well on surfaces where moisture is present
An opportunistic pathogen, but can cause allergies
Aspergillus sp.
Isolated in the environment, usually on soil and plant material
Species have green-brown colonies
Grows well in many conditions, including high-salinity or minimal nutrient areas
An opportunistic pathogen that may cause serious pulmonary infections
Trichophyton sp.
Isolated from soils, humans, or animals
Species have white-orange-brown colonies
Grows well in moist conditions
The largest cause of infections of the nails, hair, and skin
Occasionally, a mold may not be able to be identified to the genus-level using standard laboratory techniques. These molds are classified as “Non-Sporulating Fungi”, due to the lack of spore structures present. These are still considered pathogenic.
Recommendations for your cleanroom upon pathogenic results include:
Review all SOP’s in regards to personnel garbing and aseptic technique
Properly clean and disinfect any object entering controlled areas and limit any unnecessary items such as cardboard and packaging
Disinfect the sink frequently and check for any surface contamination
Ensure laminar flow of air within all spaces of the cleanroom
Ensure that minimum air changes per hour are met or exceeded
Do not store objects in controlled areas- objects that slow air flow increase the risk of contamination